DOI: 10.1039/d5cb00329f ISSN: 2633-0679
The red box: a selective G-quadruplex binder that downregulates c-MYC expression in human cells
Paula Novo, Iván Montes de Oca, Claudia García-Delgado, Agustín Sánchez-Temprano, Elena Pazos, Carlos PeinadorRed box, a fully organic macrocycle, binds the c-MYC G-quadruplex with nanomolar affinity and high selectivity over duplex DNA, and selectively downregulates c-MYC expression in cells.