DOI: 10.1039/d3md00355h ISSN:
The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)
Gregory G. Aldred, Timothy P. C. Rooney, Henriette M. G. Willems, Helen K. Boffey, Christopher Green, David Winpenny, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
- Pharmacology
- Molecular Medicine
- Biochemistry
We report the rational design of PI5P4Kα/γ dual inhibitors. ARUK2007145 (39) is disclosed as a potent, cell-active probe molecule with ADMET properties amenable to conducting experiments in cells.