The Manifestation of MicroRNA-155 in the Realm of Kidney Infection as an Envisioned Indicator of Hepatitis B Virus
Iman Mohamed Salim, Wisam Salih AboodAbstract
Background:
Chronic kidney disease (CKD) is a dangerous and quiet illness that demands trustworthy and nonintrusive indicators to accurately diagnose and predict, especially in patients infected with the hepatitis B virus (HBV). Traditional risk factors for CKD include demographics (gender and age) and lifestyles; additionally, HBV infection has been recently associated with the risk of CKD in the general population.
Objectives:
This study effort, to analyze the expression of microRNA-155 as a promising indicator of chronic kidney disease in patient with and without HBV.
Materials and Methods:
A total of 191 individuals were enlisted for the purpose of this study and sorted into the following groups: group I (consisting of 50 individuals, a healthy control group matched in terms of age and sex), group II (comprised of 50 individuals with CKD), and group III (composed of 91 individuals with CKD and HBV infection). The identification of miR-155 was accomplished through the utilization of reverse transcription polymerase chain reaction.
Results:
Our analyses found the level of serum miR-55 was significantly higher in patient groups compared to the controls (
Conclusion:
According to the results of this study, measuring the miR-155 expression levels may be used as a sensitive biomarker of CKD. MiR-155 can be utilized to distinguish between CKD with and without HBV.