The Impact of Onset Timing on 6-Month All-Cause Mortality in Hospital-Associated Pulmonary Embolism: A Retrospective Cohort Study
Jie Yao, Xing xing Zhu, Zhi hao Liu, Ya hong Sun, Li fei Huang, Huan XuBackground
The relationship between onset timing of hospital-associated pulmonary embolism (HAPE) and mortality remains unclear. This study assessed the independent prognostic role of onset timing for 6-month all-cause mortality among HAPE patients, with adjustment for the pulmonary embolism severity index (PESI) and treatment regimens.
Methods
In this retrospective cohort study, 140 HAPE patients were enrolled. According to onset time, patients were stratified into two groups: in-hospital onset (n = 94) and post-discharge onset (n = 46). Survival curves were plotted via the Kaplan-Meier (KM) methods, and intergroup differences were assessed using the log-rank test. Univariate and multivariate Cox regression were performed.
Results
Overall, 6-month mortality was 27.1% (38/140). Patients with post-discharge onset demonstrated a substantially higher mortality rate than those with in-hospital onset (39.1% vs. 21.3%,
Conclusion
Post-discharge onset was identified as an independent risk factor for 6-month all-cause mortality in patients with HAPE. Venous thromboembolism (VTE) assessment before discharge should be emphasized.