The Impact of Non-Esophageal Cancer on Tissue Systems Pathology-9 Progression Risk of Barrett’s Esophagus

The Tissue Systems Pathology-9 (TSP-9) test aids in Barrett’s esophagus (BE) risk stratification by estimating the 5-year probability of progression (PoP) to high-grade dysplasia or esophageal adenocarcinoma. The influence of a personal history of non-esophageal cancer on TSP-9 PoP is unknown. In this analysis, we found that a history of non-esophageal cancer was not associated with elevated PoP at ≥6% threshold. TSP-9 may reflect local BE biology rather than systemic oncological history, but this remains to be elucidated.