DOI: 10.4103/ijra.ijra_35_26 ISSN: 3117-4051

The Efficacy of Nasyakarma and Snehapana in the Management of Migraine: A Randomized, Open-label, Parallel-group, Clinical Trial

Sarvesh Kumar Singh, Chandra Shekhar Singh, Kshipra Rajoria, Jyoti Kumawat
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Abstract

Introduction:

This clinical trial was designed to determine and compare the efficacy of two treatment modalities, Nasyakarma (Nasal therapy) and Snehapana (Oral administration), using Vrihatajivakadya Taila (~a medicated oil) for the management of Ardhavbhedaka (~migraine).

Subjects and Methods:

This was a randomized, open-label, parallel-group, clinical trial. Sixty clinically diagnosed migraine patients were randomly assigned to either the Nasyakarma or the Snehapana . The Nasya Karma group received ~0.5 ml of Vrihatajivakadya Taila per nostril daily, while the Sneha Pana group received ~24 ml of the same oil orally after food in the evening for 14 days. The primary and secondary outcomes were to measure the changes in the migraine disability assessment scores (MIDAS) and migraine-specific quality of life scores, respectively.

Statistical Analysis Used:

The Wilcoxon matched-pairs signed-rank test and the Mann–Whitney test were used for statistical analysis. The statistical significance level was set as significant at a 5% level ( P < 0.05).

Results:

Both treatment groups demonstrated significant improvements in MIDAS and quality of life scores. However, the Nasyakarma group showed more improvement than the Snehapana group. Changes in MIDAS and migraine-specific quality of life scores were 2.533 ± 1.852 and 9.100 ± 5.268 in the Nasyakarma group and 1.600 ± 1.940 and 6.067 ± 5.564 in the Snehapana group, respectively. No serious adverse events (AEs) were reported in either group, and AEs were not related to the treatments.

Conclusions:

Nasyakarma and Snehapana have good scope in the management of migraine. Further research should focus on larger studies, objective measures, and long-term follow-up to strengthen the research evidence.

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