The effect of ferazon on structural changes in organ tissue in toxic hepatitis in experimental conditions

Objective: To analyze and evaluate the effect of ferazon on structural changes in the liver, spleen and kidneys in toxic liver damage. Materials and Methods: The study was conducted on 149 albino laboratory rats weighing 210-220 grams. For pathological analysis, the animals' liver tissue was exposed to the hepatotoxic substance CCL4 (carbon tetrachloride). The micropreparation "Ferazon" was administered to the rats intragastrically via gavage at a dose of 0.5 mg/kg. Results: After administration of ferazon at a dose of 0.5 mg/kg to animals exposed to CCL4, a pathomorphological examination of the liver showed partial restoration of the beam and lobular structure (regeneration). The tissues showed no foci of necrotic or degenerative changes in hepatocytes; instead, regenerative processes were detected. Glomeruli and nephron capsules, evenly distributed, were clearly visible in the kidney tissue. Epithelial cells of the convoluted tubules of the cortex were arranged in a single layer. In some areas, foci of cell proliferation were observed. In the medulla, the lumens of many tubules were empty, and their epithelium was virtually unchanged. Moderate lymphohistiocytic infiltration was present. Histological changes in the spleen tissue indicate restoration of lymphoid follicle structure due to proliferative changes, the absence of perivascular infiltrates, dilation of the venous sinus, and fragmentation of lymphoid follicles. Conclusion: The combined administration of ferazon and carbon tetrachloride causes structural changes in the liver, spleen, and kidneys, leading to pronounced degenerative and necrotic processes. However, animals that were administered ferazon after exposure to carbon tetrachloride demonstrated regenerative processes of cellular restoration in these organs. Based on these results, it can be concluded that ferazon has a pronounced hepatoprotective (protective) and regenerative effect.