DOI: 10.1002/rcr2.70799 ISSN: 2051-3380
The Blind Spot of
GeneXpert MTB
/
RIF
: Isoniazid‐Resistant, Rifampicin‐Susceptible Tuberculosis Detected on Phenotypic Drug Susceptibility Testing
Hafiz Muhammad Faisal Nadeem, Ali Gohar, Muhammad Faisal Jakhar, Rabbia Abbas, Taqdees Noor, Muhammad Husnain Ahmad ABSTRACT
GeneXpert MTB/RIF detects only rifampicin resistance. A 19‐year‐old man with cough and haemoptysis had rifampicin‐susceptible tuberculosis on bronchoalveolar lavage Xpert. Phenotypic drug susceptibility testing later revealed isolated isoniazid resistance, and isoniazid was replaced with levofloxacin. Additional susceptibility testing is essential to detect isoniazid‐resistant, rifampicin‐susceptible tuberculosis.