The Association of Fibronectin Levels and Lipid Peroxidation among Patients with Acute Myocardial Infarction in Babylon Province
Naser Zeyad Naser, Moaed Emran Al-Gazally, Hassan Salim AljumailyAbstract
Background:
Acute myocardial infarction (AMI) is considered one of the most threatening cardiovascular diseases, also called a heart attack, which happens when there is a blockage in the blood that flows to the heart muscle.
Materials and Methods:
A total of 90 patients with AMI were enrolled in this study, divided into two groups according to the type of AMI. Group 1 (G1) had 45 patients of ST-elevation myocardial infarction STEMI, and group 2 (G2) had 45 patients of non-ST-elevation myocardial infarction NSTEMI and 90 participants, an apparently healthy control group. The period the study extended from February 2022 till February 2023. This work was done at the Department of Biochemistry, College of Medicine, the University of Babylon, and Marjan Medical City in Hilla City, Iraq. Determination of serum fibronectin and serum malondialdehyde levels was done by human ELISA kits.
Results:
The results of the current study showed a significant increase in both serum fibronectin and malondialdehyde (MDA) levels which represent lipid peroxidation in STEMI and NSTEMI groups when compared with healthy control
Conclusion:
Current study concludes that patients with AMI in Babylon province have a statically significant association with high levels of MDA and high levels of serum fibronectin, and the increase of the serum fibronectin levels were become more clear and extreme in the G1 group when compared to G2. This pattern of results indicates the role of these markers in the formation of thrombosis, atherosclerosis, oxidative stress, and the occurrence and prognosis of myocardial infarction.