The Application of CS2 in the Synthesis of New Organic Sulfur Compounds

Abstract:

Carbon disulfide (CS2) has been widely recognized as a versatile building block in chalcogen chemistry and has attracted the research community to the synthesis of a variety of highly functionalized organic scaffolds. Conversely, carbon disulfide (CS₂) serves as a valuable chemical synthon due to its wide availability from various inexpensive sources and remarkable stability, making it a crucial substrate in organic chemistry. CS2 exhibits a versatile reactivity under mild ambient conditions for the synthesis of a library of S-containing biologically important molecules. The electrophilic nature of the carbon center, combined with the nucleophilicity of the sulfur atoms, enables CS2 to participate in a wide array of reactions, making it a key sulfur source for the introduction of sulfur functionalities into organic molecules. Moreover, the ambident nature of CS2 allows it to interact effectively with a range of nucleophiles, including amines, thiols, and organometallic reagents, leading to key intermediates such as dithiocarbamates and xanthates. This review summarizes recent developments in the use of carbon disulfide for the preparation of novel organosulfur compounds under mild reaction conditions. The sustainable techniques employed herein involve the use of non-toxic, low-cost, commercial-grade reagents and environmentally benign, greener solvents. By summarizing recent developments, this review aims to inspire further research in advancing the green synthesis of organosulfur compounds.