DOI: 10.1002/ca.70001 ISSN: 0897-3806

The Aorta‐Gonad‐Mesonephros (AGM): A Crossroads Between Hematopoiesis and Angiogenesis. A Historical Note

Domenico Ribatti

ABSTRACT

The aorta‐gonad‐mesonephros (AGM) is a region of embryonic mesoderm that develops during embryonic development from the para‐aortic splanchnopleura in chick, mouse, and human embryos. The AGM contains the dorsal aorta, genital ridges, and mesonephros, and lies between the notochord and the somatic mesoderm. The aim of this historical note was to underline the fundamental role of AGM in the development of the hematopoietic system at the crossroads between endothelial and hematopoietic cells.

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