DOI: 10.1021/acs.orglett.6c04004 ISSN: 1523-7060

Tetracarboxyphenyl Iron Porphyrin as a Robust Aqueous Catalyst to Reduce Endoperoxides

Yi Zhou, Yidan Yang, Jiubo Sun, Chong-Jing Zhang
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Abstract

We report a robust catalytic reduction of endoperoxides formed during isoluminol-based direct chemiluminescence by tetracarboxyphenyl iron porphyrin (FeTCPP). FeTCPP efficiently increased the detection sensitivity by 20-fold while saving 95% hydrogen peroxide (H2O2) compared to the traditional heme catalyst. Furthermore, FeTCPP catalytically reduced the endoperoxide of artemisinin to unexpectedly generate a main product with the scaffold of artemisinin G.

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