DOI: 10.1039/d6cs00494f ISSN: 0306-0012
Targeting toll-like receptors in the immunotherapy era: the chemistry behind TLR modulators
Marina Mínguez-Toral, Gema Fernández-Vasco, Ameerah B. Furjun, Alejandra Matamoros-Recio, Olmo Martín-Cámara, Sonsoles Martín-SantamaríaThis review summarizes the chemical diversity of TLR ligands, focusing on molecular design, structure–activity relationships, selectivity determinants, and opportunities for next-generation immunotherapeutics.