DOI: 10.1039/d6tb01432a ISSN: 2050-750X
Targeting CAF-induced oxidative phosphorylation in Dll4 + leader cells with injectable BZA-loaded MPDA hydrogel suppresses collective invasion in salivary adenoid cystic carcinoma
Xiaochen Wang, Xu Zhang, Huayang Fan, Mao Li, Ya-ling Tang, Surui ShengThe CAF–IL-6/gp130–COX17/OXPHOS axis drives Dll4 + leader cell-mediated collective invasion in SACC, and a BZA-loaded MPDA hydrogel provides a localized strategy to target this metabolic vulnerability.