DOI: 10.1126/science.aaf1292 ISSN:
T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition
Enfu Hui, Jeanne Cheung, Jing Zhu, Xiaolei Su, Marcus J. Taylor, Heidi A. Wallweber, Dibyendu K. Sasmal, Jun Huang, Jeong M. Kim, Ira Mellman, Ronald D. Vale- Multidisciplinary
Immunotherapeutic PD-1–targeted therapies require CD28 to promote cancer cell killing.