Systemic Biomarker Changes After Non‐Surgical Periodontal Treatment in Young Adults With Stage
III
/
IV
Grade C Periodontitis
Dilek Guvenc, Serdar Cintan, Pinar Soguksu, Ulku Baser, Silvi Domnori, Aslan Yasar Gokbuget, Alpdogan Kantarci ABSTRACT
Background
This study aimed to evaluate the impact of non‐surgical periodontal treatment (NSPT) on systemic inflammatory phenotype and lipid profiles in young adults with severe (Stage III–IV/Grade C) periodontitis.
Methods
Thirty systemically healthy patients with severe periodontitis and 20 healthy controls were recruited in this prospective, parallel‐group controlled study. Periodontal parameters and systemic biomarkers, including inflammatory, endothelial, and lipid biomarkers, were evaluated at baseline and re‐measured at 2 and 6 months post‐NSPT.
Results
Significant reductions in periodontal parameters were observed after 2 months and remained stable over 6 months ( p < 0.001), while bleeding, probing pocket depth, and clinical attachment levels remained significantly higher in the periodontitis patients compared to the healthy group ( p < 0.05). Circulating hs‐CRP, triglycerides, vWf, IL‐6, IL‐1ra, tPA, sTNFRII, and albumin were significantly higher while HDL cholesterol was significantly lower in periodontitis patients at baseline compared to the healthy controls ( p < 0.05). hs‐CRP, IL‐6, IL‐1ra, sTNFRI, and tPA significantly decreased; HDL cholesterol significantly increased after NSPT ( p < 0.05). HDL cholesterol, vWf, IL‐6, and sTNFRII levels remained significantly different from those of the healthy group at 6 months ( p < 0.05).
Conclusion
NSPT improved periodontal status; however, systemic biomarkers did not uniformly return to health reference levels, indicating a need for a more comprehensive medical approach.