DOI: 10.1039/d3ob01133j ISSN:

Synthesis of fused 3-trifluoromethyl-1,2,4-triazoles via base-promoted [3 + 2] cycloaddition of nitrile imines and 1H-benzo[d]imidazole-2-thiols

Kaili Cen, Jiahao Wei, Yuting Feng, Yuan Liu, Xinye Wang, Yangyu Liu, Yalin Yin, Junhong Yu, Dahan Wang, Jinhui Cai
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

This work describes the facile synthesis of fused 3-trifluoromethyl-1,2,4-triazoles via triethylamine-promoted [3 + 2] dipolar cycloaddition of nitrile imines with 1H-benzo[d]imidazole-2-thiols.

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