DOI: 10.1002/asia.202300655 ISSN:
Synthesis of Difluoromethylated Alkenes via Copper‐Catalyzed Protodefluorination of β‐(Trifluoromethyl)styrenes
Tao Dong, Yibin Ye, Yanhui Wang, Kelvin Pak Shing Cheung, Gavin Chit Tsui- General Chemistry
- Biochemistry
- Organic Chemistry
Abstract
Under typical copper‐catalyzed hydroboration conditions, β‐(trifluoromethyl)styrenes demonstrate unusal reactivities by forming difluoromethylated alkenes via a net protodefluorination process. This is also distinct from trifluoromethyl alkenes with alkyl substituents where defluoroborylation products predominate.