DOI: 10.1002/ejoc.202300702 ISSN:

Synthesis of Benzyl Thioethers by C‐S Coupling of Benzylic Trimethylammonium Salts and Sulfonyl Chlorides

Xiujuan Ma, Haoyu Jin, Min Zeng, Yiman Qin, Lili Tan, Tingting Miao, Yu Feng, Qian Shi
  • Organic Chemistry
  • Physical and Theoretical Chemistry

A facile and efficient method to synthesize thioethers from sulfonyl chlorides and benzylic trimethylammonium salts is presented. This protocol provides a simple and direct approach to realize the reductive coupling reaction of readily available sulfonyl chlorides with benzyl ammonium salts in the presence of triphenylphosphine along with base via C‐N cleavage of benzyl ammonium salts. This reaction features mild conditions and good substrates compatibility to afford thioethers in moderate to good yields.

More from our Archive