DOI: 10.1039/d3sc06444a ISSN: 2041-6520
Synthesis of axially chiral diaryl ethers via NHC-catalyzed atroposelective esterification
Yingtao Wu, Xin Guan, Huaqiu Zhao, Mingrui Li, Tianlong Liang, Jiaqiong Sun, Guangfan Zheng, Qian Zhang- General Chemistry
We present NHC-catalyzed atroposelective esterification of prochiral dialdehydes, delivering enantioenriched axially chiral diaryl ethers. Matched kinetic resolutions amplify the enantioselectivity by removing minor enantiomers via over-functionalization.