DOI: 10.1002/ange.202310004 ISSN:

Synthesis of Axially Chiral Biaryls through Cobalt(II)‐Catalyzed Atroposelective C−H Arylation

Yong‐Jie Wu, Zhen‐Kai Wang, Zhen‐Sheng Jia, Jia‐Hao Chen, Fan‐Rui Huang, Bei‐Bei Zhan, Qi‐Jun Yao, Bing‐Feng Shi
  • General Medicine


Highly efficient synthesis of axially chiral biaryl amines through cobalt‐catalyzed atroposelective C−H arylation using easily accessible cobalt(II) salt and salicyloxazoline ligand has been reported. This methodology provides a straightforward and sustainable access to a broad range of enantioenriched biaryl‐2‐amines in good yields (up to 99 %) with excellent enantioselectivities (up to 99 % ee). The synthetic utility of the unprecedented method is highlighted by its scalability and diverse transformations.

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