Synthesis of Acyl Hydrazides and Hydrazones from Activated Amides

Acyl hydrazide and acyl hydrazone synthesis methods were developed. They involve the reaction of an activated amide with hydrazine under transition metal catalyst-free conditions. Additionally, acyl hydrazones were synthesized by extending the same reaction procedure in the presence of aldehydes (or ketones). These reactions were performed in an aqueous environment at 25 oC, demonstrating the successful attainment of the desired compounds with high yields.