DOI: 10.1039/d5ra03561a ISSN: 2046-2069

Synthesis of 5-(pyrazol-4-yl) pentanoic acids and 4-(pyrazol-4-yl) butanoic acids via a cascade annulation/ring-opening reaction between hydrazone and dienone

Kalinga H. Nayak, Robert K. Jijin, Beneesh P. Babu
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A copper(

ii
) catalyzed synthesis of 5-(pyrazol-4-yl) pentanoic acid and 4-(pyrazol-4-yl) butanoic acid derivatives via an aerobic [3 + 2] annulation/ring-opening cascade pathway is described.

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