Synthesis of 3-acylated 1-aminoisoquinolin-4-ols via construction of a fully substituted pyridine moiety

A Cs ₂ CO ₃ -catalyzed reaction of 2-formylbenzonitrile with α-azidoketone under mild conditions provided 3-acyl-1-aminoisoquinolin-4-ol via construction of a fully functionalized aminopyridinol motif.