Synthesis of 1,7‐Annulated Indazole Derivatives via Bifunctional Brønsted Base Catalyzed Cascade Reaction

Comprehensive Summary

A novel method for the asymmetric synthesis of 1,7‐annulated indazoles has been developed via bifunctional Brønsted base catalyzed cascade reaction. This process enabled the formation of multiple chiral centers including a quaternary carbon center in high yields with excellent diastereoselectivities and enantioselectivities. The reaction exhibited broad functional group tolerance and mild reaction conditions.