DOI: 10.1039/d6ra08952f ISSN: 2046-2069
Synthesis, characterization, and evaluation of novel diphenylpyrazole-based hydrazine-1-carboximidamides as broad-spectrum antibacterial leads with antibiofilm and virulence-modulating activities
Sara A. Almadani, Ahmed K. B. Aljohani, Bandar D. Alrehaili, Safaa A. Turkistani, Shahad N. Almuzani, Maysa M. Aljuhani, Ghada Y. Alsayed, Ruba A. Alharbi, Hadeel Z. Alraddadi, Sobhi M. Gomha, Mohamed A. Abdelgawad, Arafa Musa, Raed Alghamdi, Mohammed S. Abdulrahman, Hany E. A. AhmedThe emergence of multidrug-resistant bacterial pathogens and biofilm-associated infections highlights the urgent need for antibacterial agents with novel chemical architectures and complementary modes of action.