Outline
DOI: 10.1039/d6ra07493f ISSN: 2046-2069
Synthesis, antitumor evaluation, and in silico investigation of pyridine-based pyrimidotriazine and triazolopyrimidine derivatives as potential EGFR-targeted anticancer agents
Sayed K. Ramadan, Ali H. Abdelrahman, Mohamed A. Hegazy, Ahmed Labena, Sobhi M. Gomha, Magdi E. A. Zaki, Mohammad E. AzabNewly synthesized pyridine-based triazolopyrimidines exhibited potent antiproliferative activity, while indole-bearing analog emerged as promising EGFR-directed candidate, supported by EGFR kinase inhibition, molecular docking, and ADME studies.
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