DOI: 10.1039/d6ra06443d ISSN: 2046-2069
Synthesis, anti-proliferative evaluation, DFT, in silico ADME and molecular modeling studies of novel imidazolones as potential EGFR inhibitors
Mohamed H. Hekal, Mohamed Abdel-Megid, Mostafa E. Salem, Saad Alrashdi, Abdullah Y. A. Alzahrani, Fatma S. M. Abu El-AzmA series of novel bromophenyl-substituted imidazolone derivatives were synthesized from ( Z )-4-(2-bromobenzylidene)-2-phenyloxazol-5(4 H )-one through reactions with various nitrogen nucleophiles.