DOI: 10.1039/d6sc02205g ISSN: 2041-6520
Synthesis and characterization of cortinarins – cryptic cyclic peptides from mushrooms of the genus Cortinarius
Zhanyu He, Celine Janssen, Joana-Lysiane Schäfer, Agnes Mühlenweg, Simone Kosol, Rene Jarling, Andi Mainz, Bettina G. Keller, Guiyang Yao, Enno Klussmann, Roderich D. SüssmuthFirst total synthesis of cortinarins A–C, cryptic cyclic peptides exhibiting non-classical atropisomerism. They mimic vasopressin-induced aquaporin-2 membrane localization through a distinct mode of action, offering leads for diabetes insipidus.