DOI: 10.1039/d6ra07150c ISSN: 2046-2069

Synthesis and biological evaluation of pyridine-based derivatives as potential inhibitors of Leishmania major propagation

Ahmed Sabt, Adnan A. Bekhit, Hanaa Farag, Huda Jawad, Kikuko Amagase, Hoda Atef Abdelsattar Ibrahim, Tamer M. Ibrahim, Abdelsamed I. Elshamy, Moataz A. Shaldam, Wagdy M. Eldehna

Fourteen hybrid molecules (3a–g, 5a–g) combining a pyridine core with thiosemicarbazone or thiazolidinone moieties were designed, synthesized, and evaluated in vitro against Leishmania major.

More from our Archive