DOI: 10.1126/science.1227166 ISSN:
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Tadahiro Shimazu, Matthew D. Hirschey, John Newman, Wenjuan He, Kotaro Shirakawa, Natacha Le Moan, Carrie A. Grueter, Hyungwook Lim, Laura R. Saunders, Robert D. Stevens, Christopher B. Newgard, Robert V. Farese, Rafael de Cabo, Scott Ulrich, Katerina Akassoglou, Eric Verdin- Multidisciplinary
Stress Protector
During prolonged fasting, the oxidation of fatty acids leads to increased accumulation of
d
-β-hydroxybutyrate (βOHB) in the bloodstream. Such increased concentrations of βOHB inhibit class I histone deacetylases. Histone acetylation in turn influences transcriptional activity at various genes.
Shimazu
et al.
(p.