DOI: 10.4103/mjbl.mjbl_625_23 ISSN: 1812-156X

Study the Association of Human Leukocyte Antigen-C and DRB1 Serum Level with Helicobacter pylori Infection

Noor Firas Qays Al-Kahachi, Noor Salman Kadhim Al-Kafaji
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Abstract

Background:

The Gram-negative, spiral-shaped Helicobacter pylori microorganism mostly affects the stomach’s pylorus and leads to chronic gastric infection. The exact method of H. pylori infection and transmission through the fecal–oral and oral–oral routes through water or food is yet unknown.

Objectives:

This study aimed to measure the serum levels of human leukocyte antigen (HLA-C) and HLA (DRB1) among patients with H. pylori and compare them with healthy controls.

Materials and Methods:

A total of 250 specimens were obtained for this case–control investigation (blood and stool). Of these, 200 specimens were from patients who were hospitalized at the Merjan Medical City Hospital in Babylon Province’s gastrointestinal and hepatology center, and 50 specimens as healthy controls.

Results:

After comparing the blood levels of HLA-C and HLA-DRB1 in sick groups with those in healthy groups, the study’s findings demonstrated that there was a significant difference ( P ≤ 0.05) in the blood levels of 6.09 ng/mL of the patients ( P < 0.000) compared with the level of healthy control of 12.89 ng/mL. When it came to HLA-DRB1, the patient’s blood level of 1905 ng/mL, whereas the healthy controls’ serum level of 2849 ng/mL ( P ≤ 0.0003).

Conclusion:

The current investigation suggests that HLA-C is one of the things that makes stomach ulcer sufferers more susceptible to infections. That might put them in danger. On the other hand, HLA-DRB1 protects against bacterial infection.

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