Study on the Preparation of Aloe Polysaccharide‐Bacterial Cellulose Composite Dressing by In Situ Mixed Culture and Its Application in Wound Healing

ABSTRACT

Bacterial cellulose (BC) possesses numerous advantages such as high tensile strength, excellent biocompatibility, and degradability, which makes it have great potential for application in medical dressing carriers. Aloe polysaccharides (AP) have significant effects in anti‐inflammation and promoting wound healing. In this experiment, nanocomposite based on BC and different concentrations of AP (0–4 wt%) were obtained by the in situ composite technique and characterized by means of SEM, FTIR, moisture content, porosity, and water vapor transmission rate. It revealed a compatible and cooperative network between BC and AP, including deep structural changes in the BC matrix shown by spectroscopic analysis. Meanwhile, the combined effect is better while the aloe polysaccharide addition rate was 2%. The tensile test and animal experiments were conducted on the 2% AP‐BC composite dressing. The results showed that the tensile strength of 2% AP‐BC was superior to that of BC, and it could effectively protect the wound surface, prevent infection, facilitate skin tissue regeneration, and wound healing. At the 12th day, its average healing rate reached 98.08%. All obtained results indicate that the 2% AP‐BC shows potential to be used as wound healing.