DOI: 10.1093/qjmed/hcad069.429 ISSN:

Study of the Relation between Serum Lipoprotein-Associated Phospholipase A2 (LP-PLA2) Level and Nonalcoholic Fatty Liver Disease (NAFLD)

Mohamamed Ali Marai Makhlof, Mohamed Magdy Slama, Gada Abd Elrahman, Huda Gomaa
  • General Medicine

Abstract

Background

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is one of the most common causes of chronic liver disease, worldwide. Lipoproteinassociated phospholipase A2 (Lp-PLA2) was recently characterized as a novel inflammatory biomarker that is correlated with several components constituting the metabolic syndrome.

Aim and Objectives

to study serum levels of Lp-PLA2 in patients with NAFLD to detect its relation to the incidence and severity of NAFLD.

Subjects and Methods

This is Case Control cross -sectional clinical Study, was carried out at Internal Medicine and Hepatology outpatient clinic at Ain Shams University Hospital on 80 persons were divided into 2 groups: (Group-I): 40 patient with NAFLD as a study group, (GroupII): Forty(40) healthy subjects as a control group.

Result

There was high statistically significant difference between the studied groups as regard LpPLA2.

Conclusion

The clinical use of Lp-PLA2, a biomarker for NAFLD, requires the standardization of analytical methods, characterization of analytical features, assessment of performance characteristics, incremental yield of different markers for given clinical indications, and demonstration of cost-effectiveness.

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