Study of the morphology of corneal endothelium and central corneal thickness in primary angle-closure suspects in relation to pseudoexfoliation syndrome in a tertiary care center
H. SushmithaAbstract
Introduction:
Pseudoexfoliation syndrome is a systemic disorder of unknown etiology, leading to primary cell changes, and is characterized by the accumulation of fibrillar material in the anterior segment of the eye and other organ systems. Primary angle-closure suspects (PACSs) more commonly present in the age group of 60 years and above. Hence, it is mandatory for ophthalmologists to do proper evaluation and prevent endothelial damage and Glaucoma.
Methods:
Sixty patients who met the inclusion criteria were included for this cross-sectional study over 18 months period, and they were divided into Group A and Group B, consisting of 30 patients each. Group A had PACSs without pseudoexfoliation, and Group B had PACSs with pseudoexfoliation. Every patient underwent a routine examination of the eyes. In all the patients, corneal endothelial morphology and central corneal thickness (CCT) were evaluated, and the results were tabulated and analyzed statistically.
Results:
The majority of subjects in both groups were found in the age group of 61–70 years. The majority of subjects in both groups were female. The mean endothelial density in Group A was more than in Group B, which was statistically significant with
Conclusion:
Our study found that Group A had better endothelial cell morphology and CCT, compared to Group B, indicating that PXF affects corneal endothelial morphology and CCT significantly.