DOI: 10.1002/cbdv.202301017 ISSN:

Structurally Diverse Metabolites from the Marine‐Derived Streptomyces sp. DS‐27 Based on Two Different Culture Conditions

Feihang Yan, Jiebin Fang, Wanjing Ding, Xinyi Tang, Xiaoming Chen, Zhongjun Ma, Jinhui Wang
  • Molecular Biology
  • Molecular Medicine
  • General Chemistry
  • Biochemistry
  • General Medicine
  • Bioengineering


Nine new compounds, including streptothiomycin A−E (15), two cyclopentenones (6, 7), one α‐pyrone (8), wailupemycin Q (20), along with sixteen known compounds were identified from a rhizosphere strain Streptomyces sp. DS‐27 derived from the marine cordgrass Spartina alterniflora under two different culture conditions. All of the structures were elucidated by extensive analysis of 1D/2D NMR and HR‐ESI‐MS data. The absolute configurations were determined by NOESY analysis, ECD, specific rotation and GIAO NMR calculations, and DP4+ probability analysis. Bioactivity investigation showed that compounds 5 and 7 exhibited significant inhibitory effects on LPS‐induced NO production in a dose‐dependent manner, which indicates their anti‐inflammatory potential.

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