DOI: 10.1002/mrc.5496 ISSN: 0749-1581
Structural Elucidation and NMR Spectral Assignments of New Diphenyl Ether Derivatives From Liuweizhiji Gegen‐Sangshen Oral Liquid
Jinghao Cui, Xin Zhou, Baorui Teng, Dan Zhang, Xiujuan Fu, Siwei Chen, Sijing Liu, Zhi Li, Hui LeiABSTRACT
Chemical investigation of the Liuweizhiji Gegen‐Sangshen oral liquid afforded one new diphenyl ether derivative (1), together with one known compound (2). Their structures were established by 1D and 2D NMR, and HR‐ESI‐MS spectroscopic analysis and the absolute configuration of 1 was confirmed by ECD calculation. Compounds 1 and 2 were evaluated for the cytotoxic activities, and compounds 1 and 2 showed weak cytotoxic activities towards HepG2 human liver cancer cells, with IC50 values of 97.3 and 79.6 μM, respectively.