DOI: 10.1093/ofid/ofad441 ISSN:
Strengthening the evidence: Similar rates of neural tube defects among deliveries regardless of maternal HIV status and dolutegravir exposure in hospital birth surveillance in Eswatini
Michelle M Gill, Philisiwe Khumalo, Caspian Chouraya, Mthokozisi Kunene, Futhi Dlamini, Heather J Hoffman, Angela E Scheuerle, Bonisile Nhlabatsi, Wiseman Mngometulu, Ntombikayise Dlamini-Madlopha, Nompumelelo Mthunzi, Lynne Mofenson- Infectious Diseases
- Oncology
Abstract
Birth defect surveillance in Eswatini in 2020-2021 identified 0.80% defects (197/24,599 live and stillborn infants). Neural tube defect (NTD) prevalence was 0.08%, 0.08%, and 0.15% for 4,902 women on dolutegravir preconception, 17,285 HIV-negative women and 1,320 women on efavirenz preconception, respectively, more definitively refuting the dolutegravir preconception NTD safety signal.