Stones, Bones, and Hormones: A Multisystem Presentation of Primary Hyperparathyroidism Due to Parathyroid Adenoma

Primary hyperparathyroidism is an endocrine disorder characterized by excessive secretion of parathyroid hormone, most commonly due to a solitary parathyroid adenoma, resulting in hypercalcemia and multisystem involvement [1]. Although many patients are diagnosed incidentally, delayed recognition may lead to severe renal, skeletal, gastrointestinal, and cardiovascular complications. We report the case of a 44-year-old male who presented with sepsis and acute kidney injury, later found to have hypercalcemia with nephrocalcinosis, chronic calcific pancreatitis, skeletal deformities, and markedly elevated parathyroid hormone levels. Imaging localized a parathyroid adenoma, and the patient underwent successful parathyroidectomy with significant biochemical and clinical improvement. This case emphasizes the importance of early consideration of primary hyperparathyroidism in patients presenting with unexplained multisystem disease and highlights the reversibility of several complications following timely surgical intervention.