DOI: 10.1039/d3sc03228k ISSN:
Stochastic assembly of biomacromolecular complexes: impact and implications on charge interpretation in native mass spectrometry
Victor Yin, Paul W. A. Devine, Janet C. Saunders, Arjan Barendregt, Fiona Cusdin, Alexandra Ristani, Alistair Hines, Sam Shepherd, Marcin Dembek, Claire L. Dobson, Joost Snijder, Nicholas J. Bond, Albert J. R. Heck- General Chemistry
An interpretative framework for analyzing by spectral simulations high resolution native mass spectra of protein assemblies is proposed. It reveals that the spectral appearances of heterogeneous assemblies can be misleadingly simple.