Stereoselective reactions of nitro compounds in the synthesis of natural compound analogs and active pharmaceutical ingredients: recent advances

Over the past decade, the chemistry of nitro compounds has been extensively developed. A particular focus of research has been placed on stereoselective transformations leading to key precursors of natural products and pharmaceutical ingredients. Most important among them are asymmetric reactions of nitroalkanes with electrophiles (e.g., Michael addition, Henry and nitro-Mannich reactions), nucleophilic additions and cycloadditions to nitroalkenes, cascade multistep processes, and novel strategies for the stereoselective introduction of the nitro group. Precise stereocontrol in these reactions is achieved through the application of new efficient organocatalysts, including solid-supported ones, as well as enzymatic and biocatalytic approaches that directly involve nitro compounds. Herein, we have systematized recently published data on the application of nitro compounds for the target-oriented stereoselective synthesis of natural and artificial bioactive molecules. The review covers the period from 2016 to 2026. <br> The bibliography includes 283 references.