Outline
DOI: 10.1039/d6cc04811k ISSN: 1359-7345
Stereochemical engineering of GLP-1 blocks proteolysis while preserving its metal-binding core
Gabriela Potoczniak, Mariusz Dziadas, Danuta Witkowska, Paweł Figurski, Beata Nowak, Magdalena Rowińska-ŻyrekSelective backbone stereochemical inversion renders GLP-1 protease-resistant without disrupting its intrinsic Zn(
ii
)/Cu(
ii
) metal-binding core.
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