DOI: 10.1002/slct.202301985 ISSN:
Spiropyrrolizidine Analogues of Rosuvastatin from N‐(4‐(4‐Fluorophenyl)‐5‐formyl‐6‐isopropylpyrimidin‐2‐yl)‐N‐methylmethanesulfonamide
Venkata Nookaapparao Gorli, Rajagopal Srinivasan- General Chemistry
Abstract
A series of spiropyrrolizidine analogues have been synthesized through 1,3‐dipolar cycloaddition of an azomethine ylide generated from isatin and L‐proline with dipolarophile which is prepared from Rosuvastatin intermediate N‐(4‐(4‐fluorophenyl)‐5‐formyl‐6‐isopropylpyrimidin‐2‐yl)‐N‐methylmethanesulfonamide and acetophenones. The stereochemistry of the cycloadduct was assigned based on the single‐crystal X‐ray structure.