DOI: 10.1021/acs.orglett.6c02744 ISSN: 1523-7060
Spiro-helicenoid Carbofluoresceins: CPL-Active Emitters for Bioimaging
Laura Erviti-Marticorena, Silvia Simón-Fuente, Sandra Míguez-Lago, José Manuel Paredes, María Ribagorda, María Dolores Girón-González, Alba Millán, Juan M. Cuerva, Delia MiguelAbstract
Chiral fluorescent probes based on small organic molecules present a promising platform for advanced bioimaging applications. In this work, we have developed a helically chiral spiro-shaped carbofluorescein with red emission (λem ≤ 613 nm). Configurationally stable enantiomers were separated, and electronic circular dichroism (ECD) and circularly polarized luminescence (CPL) evaluated. Preliminary results showed cellular permeability and intracellular emission.