DOI: 10.1039/d6ob00828c ISSN: 1477-0520
Spatiotemporally controlled degradation of CDK6 via light-triggered ROS generation: uncovering the proximity effect-mediated dual target depletion
Wei Zhang, Longli Hu, Yan He, Yu Zhang, Huan He, Silong ZhangCyclin-dependent kinase 6 (CDK6) is a key therapeutic target in breast cancer, and its abnormal activation, together with Cyclin D3, promotes uncontrolled cell proliferation.