Some Tumours Can Drive You Nuts: An Enigmatic Case of Metastatic Lymph Node
Kumudavalli Muthukumarappan, Swetha Lakshmi, Annapurneswari Subramanyan, C. S. ManiIntroduction:
NUT carcinoma (NC) is a rare aggressive undifferentiated malignant neoplasm. It can arise from midline and non-midline structures with no predilection for age and gender. NC is due to NUT gene rearrangement (Chromosomal translocation). The diagnosis is established by NUTM1 protein expression by IHC / FISH / NGS RNA sequencing Given the rarity and novelty, herein we discuss our case of NC.
Aim:
To establish a diagnosis of NUT carcinoma and its diagnostic challenges.
Clinical History:
A 23-year-old young male presented with complaints of right neck swelling.
Results:
Histopathology revealed a poorly differentiated malignant neoplasm. Immunohistochemistry showed diffuse positivity for NUTM1 protein, hence was reported as NUT carcinoma.
Conclusion:
It is an aggressive malignant neoplasm with a dismal prognosis. An integrated approach by clinicians, radiologists and pathologists is required for accurate diagnosis and timely management.