Outline
DOI: 10.1039/d6nr03117j ISSN: 2040-3364
Small-molecule-induced species redistribution drives amyloid remodeling along a conserved kinetic landscape
Radhika V. Nair, Bich Ngoc Tran, Atul N. Parikh, Matthew R. ForemanSmall-molecule modulation reshapes Aβ 42 populations with concentration. Self-clustering at higher concentrations is linked to reduced disaggregation and partial reaggregation, while molecular crowding further limits disaggregation.
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