Sleep duration and anti-müllerian hormone levels in female firefighters
Jordan A. Baker, Michelle Valenti, Leslie V. Farland, Shawn C. Beitel, James Hollister, Krystal J. Kern, Danielle Stea, Caitlin St. Clair, Miranda Olson, Heather Buren, John Gulotta, Kepra Jack, Brittany Hollerbach, Sara Jahnke, Derrick Edwards, Jefferey L. BurgessObjective
To investigate the relationship between anti-müllerian hormone (AMH) levels and sleep duration in female firefighters.
Study Design
We used baseline data collected at time of enrollment into the Women Firefighter Study, part of the Fire Fighter Cancer Cohort Study (FFCCS), including demographic information, reproductive history, and self-reported average off-duty sleep, along with serum AMH concentration.
Main Outcome Measure
We used linear regression models to estimate the association between off-duty sleep duration (categorized by <7 hours and ≥ 7 hours on average) and log transformed AMH. We adjusted for age (continuous and squared), body mass index (BMI), and oral contraception use. The formula (exp (
Results
Among 566 participants, those that reported <7 hours of sleep while off-duty had statistically significantly lower AMH levels compared to those who reported ≥ 7 hours of off-duty sleep (-18.0 %, 95% confidence interval [CI]: -32.7, -0.2).
Conclusion
Less than 7 hours of off-duty sleep was associated with lower AMH levels. Increasing off-duty sleep is a potential modifiable risk factor to benefit reproductive health in female firefighters.