Six Undescribed Dibenzocyclooctadiene Lignans With Neuroprotective Effects From Kadsura coccinea Roots

ABSTRACT

Phytochemical investigation of the roots of Kadsura coccinea led to the isolation of eleven dibenzocyclooctadiene lignans ( 1–11 ), including six new compounds ( 1–6 ). Their structures were established by HRESIMS, NMR, and ECD analyses. All isolates were evaluated for neuroprotective effects against 6‐hydroxydopamine‐induced injury in PC12 cells. Compounds 2 and 10 showed the most potent activities, increasing cell viability by 20.54% and 30.67%, respectively, at 50 µM. Mechanistic studies indicated that both compounds reduced intracellular ROS accumulation and enhanced SOD activity, while compound 10 further activated the Nrf2/HO‐1 signaling pathway. These findings suggest that dibenzocyclooctadiene lignans from K. coccinea are promising neuroprotective agents against oxidative stress‐induced neuronal injury.