DOI: 10.1093/bjd/ljag324 ISSN: 0007-0963
Single-cell RNA Sequencing Reveals a Distinct Resident Memory T Cell Phenotype in Prurigo Nodularis
Jay R Patel, Yagiz Matthew Akiska, Perya Bhagchandani, Emily Ma, Shahin Shahsavari, Davies Gage, Thomas Pritchard, Marie-France Vidaver, Madan M Kwatra, Shawn G KwatraPrurigo nodularis (PN) is a chronic inflammatory skin disease with poorly understood pathogenesis. We performed single-cell RNA sequencing on skin samples from PN patients to characterize resident memory T cell (TRM) subsets. Our findings reveal heterogeneous populations of PN CD4 TRMs in relation to the transcriptomes of atopic dermatitis and psoriasis, with immunologic heterogeneity correlating with treatment response.